In the debate, I was using SLiM. Is that what you’re calling creationist math? I guess I’ll take that as a big complement. No no, this kind of sloppy spitballing isn’t going to cut it. Here are all the parameters you’ll need to account for: Genome size in bp Per bp germline mutation rate Recombination rate Effective population size (inbreeding) Genome-wide DFE specifically for mus musculus (since DFE varies by species)