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New research reveals a shared biology behind profound fatigue in five major illnesses - including long Covid and PTSD. A new paper shows striking biological similarities between five major illnesses which until now have largely been viewed as separate disorders. The findings suggest that chronic fatigue syndrome (also known as ME), long Covid, post-traumatic stress disorder (PTSD), rheumatoid arthritis and multiple sclerosis (MS) may be driven by common underlying mechanisms. This is despite the conditions being triggered by different events - ranging from viral infections to psychological trauma or autoimmune responses.